The old term will be used for one year alongside the new, before being phased in.
Mpox was a result of lengthy discussions between experts, governments and the general public.
The WHO stated that it can be used in English just as easily as other languages.
Human monkeypox, which was first recognized in 1970, was named after the disease that was first found in captive monkeys a decade prior.
It stresses the need for a minimal negative impact on trade and travel, tourism, or animal welfare.
It was recommended that variants be referred to during the Covid pandemic using letters from the Greek alphabet as they were “non-stigmatising and easy to say”.
The unusual spread of the mpoxvirus, a member of same family viruses as smallpox, has occurred in many countries other than central and west Africa.
In July, due to a worldwide increase in symptoms like a high fever, skin lesions or rash, the WHO declared a world health emergency
While the number of cases of the disease has been declining over recent months, there have been more than 100 affected countries in 2022. This has led to a large demand for vaccines to protect those most at-risk.
Brazil, France, Spain, France, and the UK reported the highest number of mpox-related deaths this year. There have been 50 cases of the virus-related death worldwide.
After a peak in July, more than 3,500 cases have been reported by the UK. But, after an increase of 3500 cases in May, the UK began to roll out vaccines to those most at risk.
The majority of affected people were men who sex with men.